But making Hybrid ISOs is something that many Linux distributions have done to make life easier for their users. The boot loader for the MBR can be more than 32 KB, for example, or it will overwrite the ISO contents. It's an extra feature that ISO 9660 allows if done carefully. So, in summary, there's nothing to say that an ISO image should be bootable on a USB disk. A Hybrid ISO actually has two different boot loaders, one as part of ISO 9660 El Torito Boot and one for traditional disk boot. This leaves plenty of room to hide an MBR or GPT label in there with a conventional disk bootloader. Software reading the disc as ISO 9660 will always skip past that section.

It make no claims at all what can go there and will ignore whatever is there. The ISO 9660 file system has an interesting feature, it declares the first 32 kilobytes as a system area for someone else to use. What many Linux distributions use is a technique called Hybrid ISO. This means an ISO for boot must be set up completely differently from a USB drive. When the BIOS or UEFI on a computer tried to boot from a CD-ROM, it uses that and does not look for an MBR or GPT. The standard is call El Torito Boot and describes a structure that resides inside a ISO 9660 file system.

To boot a CD-ROM, it's a much different process. The GPT itself is located in the first few kilobytes of the disk. GPT is a little different and allocates something called an EFI partition elsewhere on the disk. With the MBR, the bootloader is kept with the MBR in the very first 512-byte sector on the disk. The BIOS in your computer will read the MBR or GPT from disk media and look for a boot loader there. Larger disks now use GPT, but it's similar for this discussion. Other disk-style media (including anything USB), on the other hand, start with a Master Boot Record or MBR. It is that a CD-ROM or DVD will be formatted with a file system called ISO 9660 (or a newer file system called UDF). First of all, CD-ROMs and DVDs are read by a computer differently than all other disk media.

I believe this has been answered, but I wanted to add a more detailed description of what is happening.

Burning windows 10 iso to usb